Search results for " calciphylaxis"

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A complex case of fatal calciphylaxis in a female patient with hyperparathyroidism secondary to end stage renal disease of graft and coexistence of h…

2012

Background: Calciphylaxis is a potentially fatal complication of persistent secondary hyperparathyroidism; its cause is still not clear. Unfortunately there is no close relation in severity of clinical picture, serological and pathological alteration. For this reason the prognosis is difficult to establish. Administration of sodium thiosulphate may reduce the precipitation of calcium crystals and improve the general clinical conditions before surgical parathyroidectomy, which seems the only therapeutic approach able to reduce the mortality risk in these patients. Methods and Results: A 60 year old female patient suffering from End Renal Stage Disease, on haemodialysis from 2001 due to the o…

ParathyroidectomyGraft Rejectionmedicine.medical_specialtymedicine.medical_treatmentCalciphylaxiSettore MED/08 - Anatomia PatologicaGeneral Biochemistry Genetics and Molecular BiologyEnd stage renal diseaseFatal OutcomeSecondary hyperparathyroidism; Calciphylaxis; Kidney transplant; ParathyroidectomymedicineHumansKidney transplantDialysisParathyroidectomySettore MED/14 - NefrologiaCalciphylaxisHyperparathyroidismbusiness.industryCalciphylaxisMiddle Agedmedicine.diseaseKidney TransplantationSurgeryTransplantationSecondary hyperparathyroidismSettore MED/18 - Chirurgia GeneraleHemolytic-Uremic SyndromeKidney Failure ChronicSecondary hyperparathyroidismFemaleHyperparathyroidism SecondaryComplicationbusinessBiomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
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Sodium thiosulfate not always resolves calciphylaxis: an ambiguous response

2011

Calciphylaxis is a severe “vascular ossification–calcification,” associated with a very high mortality rate that involvesarterial wall, venular wall, and nerves resulting in ischemia and necrosis of skin, subcutaneous fat, visceral organs,and skeletal muscles. Sodium thiosulfate has recently been used as a novel treatment option for calciphylaxisbecause of its dual role as an antioxidant and a chelator. Multiple case reports demonstrated that such therapy hasresulted in pain relief and healing of skin ulceration. We report a case of calciphylaxis of large severity that had anambiguous response to sodium thiosulfate treatment (improvement of symptomatology and skin lesions, improve-ment of b…

medicine.medical_specialtyNecrosisSettore MED/09 - Medicina InternaIschemiaThiosulfatesSodium thiosulfateCritical Care and Intensive Care MedicineGastroenterologySubcutaneous fatSeverity of Illness IndexAntioxidantschemistry.chemical_compoundFatal OutcomeInternal medicineSeverity of illnessmedicineHumansChelating AgentsThiosulfateCalciphylaxisbusiness.industryCalciphylaxisGeneral MedicineMiddle Agedmedicine.diseasethiosulfate calciphylaxisSurgeryTreatment OutcomechemistryNephrologyFemalemedicine.symptombusinessBlood parameters
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